Ketamine‑Assisted Psychotherapy (KAP) in Raleigh, NC

KAP involves the use of ketamine—administered and medically supervised by a licensed medical provider—combined with psychotherapy before, during, and after the ketamine experience. Ketamine can temporarily soften rigid patterns of thought and emotion, creating a window of neuroplasticity that allows therapeutic work to deepen and integrate more effectively.

At Inspired 2 Change, psychotherapy remains the core of the healing process. Ketamine is not the therapy; it is a catalyst that supports therapeutic insight, emotional release, and transformation.

KAP may be supportive for individuals experiencing:

• Depression or treatment‑resistant depression

• Anxiety

• PTSD and trauma‑related symptoms

• Chronic stress and burnout

• Emotional numbness or disconnection

• Grief and existential distress

• Feeling “stuck” despite ongoing therapy

Many clients report increased clarity, emotional release, and renewed hope.

We provide KAP within a holistic, integrative, and client‑centered framework that honors the mind, body, and spirit. Our approach includes:

1. Comprehensive Intake & Readiness Assessment

You will complete a thorough psychological assessment with your therapist and a medical evaluation with our collaborating medical provider to determine whether KAP is appropriate and safe for you.

2. Preparation Sessions

Before any ketamine session, you will meet with your therapist to set intentions, explore emotional readiness, and establish grounding tools. Preparation is essential for creating a safe, meaningful experience.

3. Ketamine Sessions (Medical Oversight Required)

Ketamine is administered by a licensed medical professional in a controlled, supportive environment. Your therapist remains present or available depending on the session type, offering emotional support and guiding you through the process as needed.

4. Integration Sessions

Integration is where the real therapeutic work unfolds. After each ketamine experience, you will meet with your therapist to process insights, emotions, and imagery, and to translate the experience into lasting change.

5. Holistic Support Options

Clients may choose to incorporate additional modalities such as:

• Reiki

• Breathwork

• Mindfulness practices

• Journey integration support

These services help deepen emotional processing and support long‑term healing.

Inspired 2 Change Life Integrated Therapy and Wellness Center, PLLC provides psychotherapy and integration services only.

All ketamine prescribing, dosing, and medical monitoring are performed exclusively by our collaborating licensed medical providers.

We maintain strict adherence to ethical guidelines, trauma‑informed care, and client safety at every stage of treatment.

KAP may be appropriate if you:

• Have tried traditional therapy or medication without sufficient relief

• Are seeking a deeper therapeutic experience

• Feel emotionally stuck or disconnected

• Are open to exploring expanded states of consciousness in a safe, structured way

• Are medically cleared by a licensed provider

KAP is not appropriate for individuals with certain medical or psychiatric conditions. A full evaluation is required.

Clients often describe ketamine‑assisted sessions as:

• Emotionally releasing and infused with Self Compassion

• Spiritually meaningful

• Stimulating clarity and insight

• Calming

• Transformative

Others may experience practical shifts such as better sleep, improved relationships, clearer boundaries, and renewed motivation. 

• Preparation and Integration Individual Sessions  (virtual/in-person)  $180.00
• Individual KAP Medical Session $250
• Financial Assistance if eligible

What the science shows about ketamine for depression, anxiety, and trauma

Growing Clinical Evidence Supports the Use of Ketamine in Mental Health Treatment

Over the past two decades, ketamine has been extensively studied for its rapid antidepressant and anxiolytic effects. Research consistently shows that ketamine can reduce symptoms of depression, PTSD, and chronic anxiety—especially for individuals who have not responded to traditional treatments.

Below is a curated, client‑friendly summary of key findings from peer‑reviewed studies.

Rapid Relief for Depression and Treatment‑Resistant Depression

Multiple randomized controlled trials (RCTs) have demonstrated that ketamine can produce rapid antidepressant effects within hours, compared to the weeks required for traditional medications.

Key Findings

• A landmark study published in Biological Psychiatry found that ketamine produced significant symptom reduction within 24 hours for individuals with treatment‑resistant depression.

• A 2020 meta‑analysis of 28 RCTs reported that ketamine showed large effect sizes for reducing depressive symptoms, with benefits lasting from several days to several weeks.

• Repeated ketamine sessions were associated with longer‑lasting improvements and reduced suicidal ideation.

Promising Results for PTSD and Trauma‑Related Symptoms

Ketamine’s ability to disrupt rigid neural patterns makes it a promising tool for trauma recovery.

Key Findings

• A 2021 RCT published in The American Journal of Psychiatry found that ketamine led to significant reductions in PTSD symptoms compared to placebo.

• Participants receiving ketamine showed improvements in intrusive memories, avoidance, and hyperarousal.

• When paired with psychotherapy, ketamine appears to enhance emotional processing and reduce trauma‑related distress.

Reduction in Anxiety and Chronic Stress

Ketamine’s impact on glutamate and neuroplasticity may help reduce anxiety symptoms and support emotional flexibility.

Key Findings

• A 2022 systematic review found that ketamine produced moderate to large reductions in generalized anxiety symptoms, often within hours.

• Studies suggest ketamine may help “reset” overactive stress circuits, improving emotional regulation and reducing chronic worry.

Enhanced Neuroplasticity and Emotional Insight

Ketamine temporarily increases neuroplasticity—your brain’s ability to form new connections.

Key Findings

• Research shows ketamine increases BDNF (brain‑derived neurotrophic factor), a protein essential for learning, emotional healing, and cognitive flexibility.

• This neuroplastic window may make psychotherapy more effective, allowing clients to access insights, release emotional blocks, and integrate new patterns.